The Platelet-rich Plasma or PRP has already become a famous type of treatment for both degenerative injuries and athletic injuries such as ligament and tendon injuries. In this article we will discuss what is PRP.
Platelets are found in your blood that functions by formation clots. But, these also contain a good number of proteins which are very important in interacting with the other stem cells and red blood cells.
The theory states that its bioactive substances would aid in accelerating the healing processes of all soft tissues. Majority of the soft tissues like ligaments, cartilages, and tendons have very poor blood supplies. That means that the time that is required to heal them would have to be longer.
The PRP is composed of growth factors that will stimulate the creation blood vessels. This is a process called neovascularization. This promotes in transporting all the required nutrients for the regeneration of the damaged or diseased tissues. These factors consist of the TGF, platelet derived factor, vascular endothelial growth factors, epidermal growth factors, fibroblast growth factors, and many more.
The PRP is acquired by means of centrifuging the specimen of the patient's whole blood. This would separate blood into its different components that include white blood cells, red blood cells, plasma, and platelets. The PRP must contain at least 5x the baseline concentrations of the platelets in the blood. Thus, since the typical platelet count is just around 250,000 per microliter, the best PRP specimen would contain for over a million platelets.
The PRP specimen's quality could be affected by certain factors like the general health of the patient, current medications, circadian rhythm, and the occurrence of dehydration.
The platelets contain huge alpha granules which serve as the repositories for the growth factors. Of course, these cells could be activated by the help of various substances that are present in the blood.
These elements are the serotonin, thrombin, magnesium, and calcium. Also, platelets could be activated by means of smoking.
Whenever they are activated, they would discharge all their growth factors.
The growth factors could stimulate the healing procedures by means of creating new blood vessels, enticing inflammatory cells and stem cells into the place to aid in constructing brand new tissues, cellular multiplication, and cellular differentiation.
Patients who have both quantitative and qualitative abnormalities in their platelets are most probably not the best candidates for this kind of treatment. Proper manipulation and sterile methods of the specimen should be done. The medicines that act as platelet inhibitor should be stopped before performing the procedure.